Annu Rev Biochem 51:531–554īlack PH (1979) Shedding from the cell surface of normal and cancer cells. Lab Invest 30:35–42Īshwell G, Harford J (1982) Carbohydrate-specific receptors of the liver. A cytodynamic study in mice after exposure to oxygen. It is concluded that: (1) heat-stable alkaline phosphatase is a specific constitutent of type-I pneumocytes in man and monkeys and (2) its subcellular localization may explain its rapid appearance in the circulation under certain conditions.Īdamson IYR, Bowden DH (1974) The type 2 cell as progenitor of alveolar epithelial regeneration. In human fetal lung, the onset of heat-stable alkaline phosphatase expression was associated with the development of the alveolar epithelium from 17–20 weeks gestation onward. The level of heat-stable alkaline phosphatase expression in the human lung was 10-fold lower than in the monkeys studied. Staining was localized on the apical and basal plasma membrane, in apical and basal caveolae, and in the underlying basement membrane. In man, strong staining was observed only in some type-I cells and in certain cuboidal respiratory bronchiolar cells. In the monkey, the enzyme was found in all type-I cells. ![]() Both in man and monkey, the enzyme was present in type-I pneumocytes. fascicularis) lung was investigated at the light- and electron-microscopic level, using cytochemical techniques and immunocytochemical procedures based on monoclonal and polyclonal antibodies against human term-placental alkaline phosphatase. The expression of the heat-stable isoenzyme of alkaline phosphatase in the human and monkey ( Macaca mulatta, M.
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